Patent-pending supplement platform

Restore what long-term PPIs quietly take away.

Repletex is a patent-pending dietary supplement platform. The lead product, Repletex PPI Recovery Support, is in development for long-term proton pump inhibitor users. A two-capsule daily routine of bioavailable nutrients, gastric support, and microbiome restoration, backed by FDA communications and peer-reviewed research.

Register interest For acquirers and licensees
  • FDA safety communication referenced
  • USPTO patent-pending
  • Peer-reviewed dosing rationale

For PPI users

PPIs help manage acid. Years of use can quietly create nutritional blind spots.

Proton pump inhibitors like omeprazole, esomeprazole, pantoprazole, and lansoprazole are widely prescribed and often essential. The trade-off, documented in FDA communications and clinical literature, is a pattern of nutrient absorption challenges that can develop slowly over years of treatment.

01

Bone health concerns

Magnesium and calcium absorption changes have been linked, in long-term PPI users, to increased fracture risk and accelerated bone loss.

02

Vitamin status drift

Reduced absorption of food-bound vitamin B12, plus lower vitamin C bioavailability, are repeatedly described in chronic PPI populations.

03

Mineral and trace element loss

Zinc absorption is impaired in low-acid environments, with downstream effects on immunity, wound healing, and metabolic function.

04

Gastrin and microbiome shifts

Sustained acid suppression elevates gastrin and changes the gut environment, with relevance to long-term gastric and digestive health.

The patent-pending formula

A purpose-built two-capsule daily routine, not a generic multivitamin.

Every ingredient and dose was selected from peer-reviewed clinical literature with the long-term PPI user in mind. Bioavailable forms, low-acid considerations, and four distinct mechanisms working together.

Ten ingredients. Four mechanisms. Each chosen for the low-acid environment.

Exact dosing under NDA
  • Repletion

    Magnesium

    Bisglycinate

    Chelated form chosen for absorption stability in the low-acid environment most documented to challenge magnesium status in long-term PPI users.

  • Repletion

    Calcium

    Citrate

    Acid-independent calcium form, more reliably absorbed when gastric acid is suppressed. Standard form preferred in chronic-acid-blockade populations.

  • Bone

    Vitamin K2

    MK-7, long-acting

    Directs calcium into bone tissue rather than soft tissue. Pairs with vitamin D3 and boron to complete a true bone-support stack.

  • Bone

    Vitamin D3

    Cholecalciferol

    Anchors the bone-support arm of the formula. Selected at a level supported by mainstream clinical guidance.

  • Bone

    Boron

    Citrate

    Trace mineral that complements calcium, vitamin D3, and vitamin K2 for skeletal mineralization.

  • Repletion

    Vitamin B12

    Methylcobalamin

    Active, pre-converted form. Bypasses the gastric-acid-dependent step required to release food-bound B12, the precise step disrupted by PPIs.

  • Repletion

    Zinc

    Picolinate

    Bioavailable zinc form, included to address absorption impairment under chronic acid suppression.

  • Repletion

    Vitamin C

    Ascorbic acid

    Targets the reduced vitamin C bioavailability described in long-term PPI users.

  • Gastric

    Broccoli sprout extract

    Sulforaphane-rich

    The differentiating ingredient. Sulforaphane is the most potent natural Nrf2 activator known. Peer-reviewed work from Fahey and Talalay at Johns Hopkins, and from Yanaka and colleagues in human subjects, documents activity in gastric mucosa relevant to long-term PPI users.

  • Microbiome

    Probiotic blend

    Multi-strain, live cultures

    Counters the dysbiosis associated with sustained acid suppression. Forms the microbiome arm of the four-mechanism design.

Exact dosing, ratios, and clinical rationale Available in the full diligence packet under NDA. Request access in the form below.

Four mechanisms working together

Why each ingredient earns its place.

Nutrient repletion

Magnesium, calcium, B12, vitamins D and C, and zinc in bioavailable forms designed for low-acid environments.

Bone health support

Vitamin D3, K2 MK-7, and boron work synergistically to direct calcium into bone and support skeletal retention.

Nrf2 activation in the gastric environment

Sulforaphane from broccoli sprout extract is the most potent natural activator of the Nrf2 pathway, the cell's master regulator of antioxidant and cytoprotective enzymes. Peer-reviewed work has documented activity in the gastric mucosa.

Microbiome restoration

A multi-strain probiotic blend at clinically supported levels addresses the dysbiosis associated with sustained acid suppression.

How Repletex compares

Why a generic multivitamin or a stack of single nutrients does not solve this.

Long-term acid suppression changes how minerals and B12 are absorbed. The right answer is a formula built for that environment, not a generalist.

Built for this

Repletex PPI Recovery Support

  • Designed specifically for long-term PPI users
  • Bioavailable forms selected for a low-acid environment
  • Four mechanisms: repletion, bone, gastric, microbiome
  • Ten ingredients in one daily routine
  • Two capsules per day, one bottle on the counter
Generic multivitamin

A daily multi was not designed for acid suppression.

  • Broad coverage, not PPI-specific
  • Often uses calcium carbonate, which depends on gastric acid
  • Generic cyanocobalamin B12, not the active methylated form
  • No gastric environment support
  • No probiotic to address PPI-associated dysbiosis
Single-nutrient stack

Targeted, but fragmented and easy to abandon.

  • Right idea on individual nutrients
  • Five to seven separate bottles to coordinate
  • No gastric or microbiome arm of the formula
  • Higher total cost and lower compliance over time
  • No unified mechanism story for clinicians or buyers

Evidence base

FDA-acknowledged. Peer-reviewed. Built to brief well in any boardroom.

Low magnesium levels can be associated with long-term use of Proton Pump Inhibitor (PPI) drugs.
FDA Drug Safety Communication

Selected peer-reviewed support

For acquirers and licensees

A protected consumer health asset positioned for category creation.

Repletex delivers a clean entry into a large, medication-adjacent population already focused on digestive health, daily routines, and physician-guided wellness. The asset is structured for an exclusive license, acquisition, or royalty arrangement.

01

First-mover positioning

Zero direct PPI companion supplements on shelf today. A focused brand can claim the category before it becomes crowded.

02

Patent-pending IP

The PPI Recovery Support formula is patent-pending. Five additional patent applications extend the platform across major drug classes.

03

Manufacturing-ready

Established supplement inputs and a clean-label profile. Designed for scalable contract manufacturing with strict quality control.

04

Strong unit economics

Designed for premium retail pricing with attractive gross margin at scale. Detailed cost-of-goods and revenue modeling available under NDA.

05

Regulatory clarity

Classified as a dietary supplement. No NDA or ANDA required. FDA structure and function claim language is permitted.

06

Clear distribution paths

Healthcare practitioner channels, physician recommendation, direct-to-consumer education, and retail partnerships.

Platform expansion

Repletex is not a single product. It is a platform for drug-induced nutrient depletion.

Beyond proton pump inhibitors, the team has filed five additional patent applications addressing nutrient depletion linked to other major drug classes. Each represents a large chronic-use population with similar education and channel dynamics.

150M+

Americans on chronic medications across these six classes, the addressable population the Repletex platform is designed to serve.

Concept visualization of a future Repletex product line on a retail shelf, showing branded bottles for PPI, biguanide, SSRI, ACE inhibitor, and diuretic medication classes.
Concept visualization A representation of where the Repletex platform points. No Repletex product is currently for sale. The PPI Recovery Support formula is the lead product, patent-pending and in development. The other categories are patent-filed and earlier-stage.
Repletex Platform IP
  • PPIs Lead product

    omeprazole · esomeprazole · pantoprazole · lansoprazole

  • ACE Inhibitors Patent filed

    lisinopril · enalapril · ramipril · benazepril

  • Beta Blockers Patent filed

    metoprolol · atenolol · propranolol · carvedilol

  • Diuretics Patent filed

    hydrochlorothiazide · furosemide · spironolactone

  • SSRIs Patent filed

    fluoxetine · sertraline · paroxetine · escitalopram

  • Metformin Patent filed

    metformin · Glucophage · Glumetza · Fortamet

Drug coverage reference

Drugs the Repletex platform addresses.

A reference for users, prescribers, and acquirers. Each entry lists representative generic and brand-name drugs in the class, the nutrient depletion patterns documented in clinical literature, and Repletex platform status.

Lead product

Proton Pump Inhibitors (PPIs)

Generic
omeprazole, esomeprazole, pantoprazole, lansoprazole, rabeprazole, dexlansoprazole
Brand
Prilosec, Nexium, Protonix, Prevacid, Aciphex, Dexilant, Zegerid
Common conditions
GERD, acid reflux, peptic ulcer, Barrett's esophagus
Documented depletion
magnesium, calcium, vitamin B12, vitamin C, zinc, plus gastrin elevation and microbiome shifts
Patent filed

ACE Inhibitors

Generic
lisinopril, enalapril, ramipril, captopril, benazepril, quinapril, fosinopril, trandolapril, moexipril, perindopril
Brand
Prinivil, Zestril, Vasotec, Altace, Capoten, Lotensin, Accupril, Mavik, Univasc, Aceon
Common conditions
hypertension, heart failure, diabetic nephropathy, post-MI cardioprotection
Documented depletion
zinc, with associated effects on taste, immunity, and wound healing
Patent filed

Beta Blockers

Generic
metoprolol, atenolol, propranolol, carvedilol, bisoprolol, nebivolol, labetalol, pindolol, sotalol, timolol
Brand
Lopressor, Toprol XL, Tenormin, Inderal, Coreg, Zebeta, Bystolic, Trandate, Visken, Betapace
Common conditions
hypertension, atrial fibrillation, angina, heart failure, migraine prophylaxis
Documented depletion
coenzyme Q10 (CoQ10), with emerging evidence on melatonin
Patent filed

Diuretics

Generic
hydrochlorothiazide (HCTZ), chlorthalidone, indapamide, metolazone, methyclothiazide, furosemide, bumetanide, torsemide, ethacrynic acid, spironolactone, eplerenone, amiloride, triamterene
Brand
Microzide, Lasix, Aldactone, Demadex, Bumex, Inspra, Zaroxolyn, Edecrin
Common conditions
hypertension, edema, heart failure, ascites
Documented depletion
potassium, magnesium, sodium, thiamine (vitamin B1), zinc, calcium
Patent filed

SSRIs

Generic
fluoxetine, sertraline, paroxetine, citalopram, escitalopram, fluvoxamine, vilazodone, vortioxetine
Brand
Prozac, Zoloft, Paxil, Celexa, Lexapro, Luvox, Viibryd, Trintellix
Common conditions
depression, generalized anxiety, OCD, panic disorder, PTSD
Documented depletion
melatonin, folate, B vitamins, sodium (with hyponatremia risk)
Patent filed

Metformin

Generic
metformin (immediate and extended release)
Brand
Glucophage, Glumetza, Fortamet, Riomet
Common conditions
type 2 diabetes, prediabetes, polycystic ovary syndrome (PCOS)
Documented depletion
vitamin B12 (most documented), folate, coenzyme Q10

Drug names appear here as a clinical reference. Brand names are trademarks of their respective owners. The Repletex platform is positioned to support nutritional needs associated with chronic use of these medication classes and is not intended to diagnose, treat, cure, or prevent any disease, nor to replace medical care.

Two ways to engage

Get on the list, or start a diligence conversation.

Long-term PPI users join the waitlist for launch updates. Acquirers and licensees receive the diligence packet under NDA. We will email you a confirmation either way.

Only email is required. We will send you a confirmation as soon as you submit.

We use your details only for launch updates and diligence follow-up. No third-party sharing. See our Privacy Policy.

How people actually ask

Plain-English questions, plain-English answers.

The phrasings below are how real users type into Google or ask Siri, Alexa, ChatGPT, Claude, or Perplexity when they're trying to figure out what their medication is doing to their nutrition.

"Is there anything to replenish what I'm losing on omeprazole?"

Yes. Repletex PPI Recovery Support is a patent-pending dietary supplement formulated specifically for long-term users of omeprazole (Prilosec) and other proton pump inhibitors. It pairs bioavailable magnesium, calcium, vitamin B12, zinc, vitamin C, vitamin D3, vitamin K2 MK-7, boron, broccoli sprout extract, and a multi-strain probiotic in forms designed for the low-acid environment chronic acid suppression creates.

"What vitamins should I take with my PPI?"

If you take a long-term PPI such as omeprazole, esomeprazole, pantoprazole, or lansoprazole, the nutrients most discussed in clinical literature are magnesium (bisglycinate for absorption), calcium citrate (acid-independent), methylcobalamin B12, vitamin D3, vitamin K2 MK-7, vitamin C, zinc, and a multi-strain probiotic. Repletex is built around exactly this pattern. Always check with your prescriber.

"Does Prilosec or Nexium cause vitamin deficiency?"

Long-term Prilosec (omeprazole), Nexium (esomeprazole), Protonix (pantoprazole), Prevacid (lansoprazole), Aciphex (rabeprazole), and Dexilant (dexlansoprazole) are associated, in FDA Drug Safety Communications and peer-reviewed clinical literature, with reduced absorption of magnesium, calcium, vitamin B12, vitamin C, and zinc. Bone health and gut microbiome shifts are also documented.

"I take Nexium daily, what should I supplement with?"

Daily Nexium (esomeprazole) users are commonly advised to monitor magnesium, calcium, vitamin B12, vitamin C, and zinc. Repletex PPI Recovery Support delivers all of these in bioavailable forms appropriate for a low-acid environment, plus vitamin D3, vitamin K2 MK-7, boron, broccoli sprout extract, and a multi-strain probiotic in one two-capsule daily routine.

"What can I take to fix what metformin is doing to my B12?"

Long-term metformin (Glucophage, Glumetza, Fortamet, Riomet) commonly reduces vitamin B12 absorption, sometimes folate, and can affect CoQ10. Methylcobalamin is typically the preferred B12 form because it skips an absorption step. The Repletex platform has a patent application filed for a metformin-specific repletion formula. Loop in your prescriber, especially for diabetes or PCOS use.

"I'm on lisinopril, what nutrients am I losing?"

Long-term lisinopril (Prinivil, Zestril) and other ACE inhibitors like enalapril (Vasotec), ramipril (Altace), captopril (Capoten), benazepril (Lotensin), and quinapril (Accupril) have been linked to reduced zinc status, with downstream effects on taste, immunity, and wound healing. A Repletex ACE-inhibitor-specific formula is in patent-filed development.

"Does my blood pressure medication deplete potassium or magnesium?"

Thiazide and loop diuretics commonly prescribed for blood pressure, such as hydrochlorothiazide (Microzide), chlorthalidone, indapamide, furosemide (Lasix), bumetanide, and torsemide, are widely associated with potassium, magnesium, sodium, and thiamine (vitamin B1) loss. Zinc and calcium may also be affected. A Repletex diuretic-specific formula is patent-filed.

"What's the best supplement for someone on long-term acid blockers?"

A targeted formula matters more than a generic multivitamin because chronic acid suppression changes how minerals and B12 are absorbed. Look for magnesium bisglycinate, calcium citrate (not carbonate), methylcobalamin B12, zinc picolinate, vitamin D3, vitamin K2 MK-7, and a probiotic. Repletex PPI Recovery Support is built around this exact pattern.

Frequently asked

Quick answers

Is Repletex intended to replace omeprazole or other PPIs?

No. Repletex is positioned as nutritional support for long-term PPI users. It is not a replacement for medication or medical advice.

What is a PPI companion supplement?

A dietary supplement formulated around the nutritional patterns commonly discussed with long-term proton pump inhibitor use, including magnesium, calcium, vitamin D, vitamin B12, vitamin C, zinc, and gut microbiome support.

How is this different from a regular multivitamin?

Repletex is built around PPI-specific needs and the low-acid environment created by chronic acid suppression. It uses bioavailable forms such as magnesium bisglycinate, calcium citrate, methylcobalamin B12, zinc picolinate, vitamin K2 MK-7, broccoli sprout extract, and a multi-strain probiotic blend.

Can users take this with a PPI?

The concept is designed to sit alongside PPI therapy. Users should consult their healthcare professional before starting any supplement, especially with kidney disease, blood thinners, thyroid medication, or pregnancy.

What is the patent status?

The PPI Recovery Support formula is patent-pending. Five additional patent applications extend the platform to ACE inhibitors, beta blockers, diuretics, SSRIs, and metformin.

What can an acquirer access?

Qualified acquirers can request the full diligence packet, including the patent application overview, formulation rationale, cost structure, channel strategy, and revenue modeling under NDA.

Does metformin cause vitamin B12 deficiency?

Yes. Long-term metformin (Glucophage, Glumetza, Fortamet, Riomet) is well documented to reduce vitamin B12 absorption. The American Diabetes Association recommends periodic B12 testing for chronic metformin users. Folate and CoQ10 may also be affected. The Repletex platform has a patent application filed for a metformin-specific repletion formula.

Do ACE inhibitors deplete zinc?

Yes. Long-term use of ACE inhibitors such as lisinopril (Prinivil, Zestril), enalapril (Vasotec), ramipril (Altace), captopril (Capoten), and benazepril (Lotensin) has been linked to reduced zinc status, with downstream effects on taste, immunity, and wound healing. The Repletex platform has a patent application filed for an ACE-inhibitor-specific repletion formula.

Do beta blockers deplete CoQ10?

Yes. Beta blockers including metoprolol (Lopressor, Toprol XL), atenolol (Tenormin), propranolol (Inderal), carvedilol (Coreg), bisoprolol (Zebeta), and nebivolol (Bystolic) have been associated with reduced coenzyme Q10 levels, with emerging evidence on melatonin. The Repletex platform has a patent application filed for a beta-blocker-specific repletion formula.

Do diuretics cause potassium and magnesium loss?

Yes. Thiazide and loop diuretics including hydrochlorothiazide (Microzide), chlorthalidone, indapamide, furosemide (Lasix), bumetanide, and torsemide are widely associated with potassium, magnesium, sodium, and thiamine (vitamin B1) loss. Zinc and calcium can also be affected. The Repletex platform has a patent application filed for a diuretic-specific repletion formula.

Do SSRIs cause nutrient depletion?

SSRIs including fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), citalopram (Celexa), escitalopram (Lexapro), and fluvoxamine (Luvox) have been associated in emerging literature with shifts in melatonin, B vitamins, folate, and sodium status with long-term use. The Repletex platform has a patent application filed for an SSRI-specific repletion formula.

What drugs does the Repletex platform cover?

Six high-prevalence chronic medication classes: proton pump inhibitors (lead product, in development), ACE inhibitors, beta blockers, diuretics, SSRIs, and metformin. Patent applications have been filed for each category. No Repletex product is currently for sale.

Safety and interactions

When to talk to your prescriber before starting Repletex.

Repletex contains nutrient forms that are widely used in clinical literature but still warrant attention in specific situations. Read this list and run it by your healthcare professional before starting any supplement.

Warfarin and other vitamin K-dependent anticoagulants

Repletex contains vitamin K2 (MK-7). Vitamin K of any form can reduce the anticoagulant effect of warfarin (Coumadin, Jantoven) and may shift INR. If you take warfarin, do not start Repletex without your prescriber adjusting and monitoring your INR. Direct-acting oral anticoagulants such as apixaban (Eliquis), rivaroxaban (Xarelto), dabigatran (Pradaxa), and edoxaban (Savaysa) are not affected by vitamin K, but still confirm with your clinician.

Chronic kidney disease and dialysis

People with reduced kidney function clear magnesium less efficiently and can develop hypermagnesemia from supplemental doses that healthy kidneys handle without issue. If you have chronic kidney disease, especially stage 4 or 5, are on dialysis, or have a known low estimated glomerular filtration rate, do not start Repletex without nephrology guidance.

Severe immunocompromise

Repletex contains a multi-strain probiotic blend. Live probiotic cultures are widely tolerated, but rare cases of bacteremia or fungemia have been reported in severely immunocompromised individuals, including bone-marrow or organ transplant recipients, people on strong immunosuppressants, those with neutropenia, and people with central venous catheters. Do not start Repletex in these situations without infectious-disease oversight.

Pregnancy and lactation

Repletex is intended for adult long-term PPI users and has not been evaluated for use during pregnancy or breastfeeding. Some ingredients, including vitamin K2 MK-7 and broccoli sprout extract, do not have well-established safety data in these populations. If you are pregnant, planning pregnancy, or breastfeeding, do not start Repletex without your obstetrician or lactation provider.

Thyroid medication and other timing-sensitive drugs

Calcium and other minerals can interfere with absorption of levothyroxine (Synthroid, Levoxyl), tetracyclines, fluoroquinolones, and bisphosphonates. Take those medications on their usual empty-stomach schedule and separate Repletex by at least two to four hours.

Spacing Repletex from your PPI dose

Most people take their PPI first thing in the morning. To give the supplemented minerals and B12 the best chance to absorb, take Repletex with your largest meal, ideally at least two hours after the PPI dose. The window is not strict, but later in the day works better than alongside the medication.

This list is not exhaustive. Talk with your prescriber before starting any supplement, especially if you have a chronic medical condition, take prescription medication, or are managing more than one diagnosis at a time. Repletex is a dietary supplement, not a replacement for medical care.